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  • Title: Synthesis of glycosylated beta-amino acids as new class of antitubercular agents.
    Author: Tripathi RP, Tripathi R, Tiwari VK, Bala L, Sinha S, Srivastava A, Srivastava R, Srivastava BS.
    Journal: Eur J Med Chem; 2002 Sep; 37(9):773-81. PubMed ID: 12350294.
    Abstract:
    A series of glycosylated beta-amino acids was prepared and evaluated against Mycobacterium tuberculosis, M. avium, M. fortuitum and M. smegmatis. The compounds were designed to mimic the enzyme D-alanine racemase and glycosyl transferase involved in the biosynthesis of essential cell wall peptidoglycan and arabinogalactan. Though most of the compounds exhibited little activity, however, one showed significant activity against all the strains in cell culture and activity was confirmed by BACTEC method.
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