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  • Title: Klinefelter's syndrome and precocious puberty: a harbinger for tumor.
    Author: Kurzrock EA, Tunuguntla HS, Busby JE, Gandour-Edwards R, Goldman LA.
    Journal: Urology; 2002 Sep; 60(3):514. PubMed ID: 12350505.
    Abstract:
    Boys with Klinefelter's syndrome are at an increased risk of precocious puberty. Most cases are either idiopathic or due to a mediastinal tumor. Patients with Klinefelter's syndrome are at a high risk of primary, extragonadal germ cell tumors, which are usually nonseminomatous, but can be a mixed type with seminomatous elements. The differential diagnosis of precocious puberty includes mediastinal tumors, especially in boys with Klinefelter's syndrome.
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