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  • Title: Induction of pancreatic neoplasms by 2,2'-dioxopropyl-N-propylnitrosamine.
    Author: Pour P, Althoff J, Krüger F, Schmähl D, Mohr U.
    Journal: Cancer Lett; 1975 Sep; 1(1):3-6. PubMed ID: 1235057.
    Abstract:
    A high incidence of pancreatic duct adenomas and carcinomas were induced in Syrian golden hamsters as early as 13 weeks after chronic administration of 2,2'-dioxopropyl-n-propylnitrosamine (DOPN) at a 10 mg/kg dose. In contrast to another pancreatic carcinogen, 2,2'-dihydroxy-propyl-n-propyl-nitrosamine, DOPN induced no tumors of the upper respiratory tract or kidneys, and only a few neoplasms of the lungs and liver.
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