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  • Title: The binding of dimethylnitrosamine to nucleic acids catalyzed by liver enzymic fractions.
    Author: Grilli S, Bragaglia R, Prodi G.
    Journal: Cancer Lett; 1975 Nov; 1(2):85-90. PubMed ID: 1235064.
    Abstract:
    The in vitro binding of a metabolite of dimethylnitrosamine (DMNA) to calf thymus DNA catalyzed by a microsomal system from rat liver is reported. The amount ob binding is unaffected by using microsomes induced by 3-methylcholanthrene and/or normal or induced pH 5 enzymes. The microsomal system is also effective in catalyzing covalent binding of the nitroso compound with synthetic polyribonucleotides.
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