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  • Title: Circulatory regulation in anuric rats: anuria and haemorrhagic hypotension.
    Author: Debreczeni LA, Albert K, Takács L.
    Journal: Acta Physiol Acad Sci Hung; 1975; 46(2):151-62. PubMed ID: 1235232.
    Abstract:
    In rats made anuric by ureteral ligation or by creating a bladder-caval venous shunt, cardiac index increased and total peripheral resistance decreased proportionally to the change in the serum NPN level. Circulating blood and plasma volume did not change. In ureteral-ligated or bladder-caval venous-shunted rats, cardiac output and its organ fractions were determined by SAPIRSTEIN'S technique. In the ureteral-ligated animals, vasoconstriction in the kidneys, and vasodilation in the skin were found. After bladder-caval shunt, vasodilatation developed in the myocardium, gut, skin and carcass. After ureteral ligation, posthaemorrhagic shifting decreased mainly the renal flow, while after a bladder-caval venous shunt, mainly the renal and intestinal flows.
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