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  • Title: Oligodendrocyte-myelin glycoprotein (OMgp) is an inhibitor of neurite outgrowth.
    Author: Kottis V, Thibault P, Mikol D, Xiao ZC, Zhang R, Dergham P, Braun PE.
    Journal: J Neurochem; 2002 Sep; 82(6):1566-9. PubMed ID: 12354307.
    Abstract:
    A protein fraction purified from bovine brain myelin, previously called arretin because of its ability to inhibit neurite outgrowth, has been identified as consisting predominantly of oligodendrocyte-myelin glycoprotein (OMgp). We show that it is a potent inhibitor of neurite outgrowth from rat cerebellar granule and hippocampal cells; from dorsal root ganglion explants in which growth cone collapse was observed; from rat retinal ganglion neurons; and from NG108 and PC12 cells. OMgp purified by a different procedure from both mouse and human myelin behaves identically in all bioassays tested.
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