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  • Title: Extranodal Rosai-Dorfman disease involving the meninges.
    Author: Franco-Paredes C, Martin K.
    Journal: South Med J; 2002 Sep; 95(9):1101-2. PubMed ID: 12356124.
    Abstract:
    Rosai-Dorfman disease is an idiopathic histiocytic proliferative disorder characterized by sinus histiocytosis and massive lymphadenopathy. Extranodal involvement has also been reported. We report the case of a 57-year-old woman presenting with seizures, focal motor deficits, and leptomeningeal enhancement on magnetic resonance imaging. Meningeal biopsy revealed Rosai-Dorfman disease. Sinus histiocytosis may mimic meningeal disease, and Rosai-Dorfman disease should be considered in the differential diagnosis of dural-based masses with diffuse leptomeningeal enhancement.
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