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  • Title: [Novel therapeutic approach to amyloidosis: no implications as yet for patients with Alzheimer's disease].
    Author: Lemstra AW, Eikelenboom P, Meijer EW, van Gool WA.
    Journal: Ned Tijdschr Geneeskd; 2002 Sep 14; 146(37):1720-3. PubMed ID: 12357871.
    Abstract:
    Many disorders, such as Alzheimer's disease and diabetes, are characterised by the misfolding and aggregation of proteins. Pepys et al. described a new approach of destabilizing these aggregates by removing an associated protein, serum amyloid P. This offers opportunities for treating amyloidosis and possibly other protein folding diseases. Understanding the mechanism of this unique disease process and the different elements involved is necessary for future drug development.
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