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  • Title: [Action of clostridial spores on transplantation tumors in alloxan-diabetic rats (author's transl)].
    Author: Ludewig R, Hambsch K, Kretschmer H.
    Journal: Arch Geschwulstforsch; 1975; 45(8):795-801. PubMed ID: 1235792.
    Abstract:
    With the intention to improve the up to now unsatisfying effectiveness of tumour treatment by clostridial spores, the influence of Alloxan-induced hyperlglycemia on clostridial therapy in two transplantable tumours of the rat are examined. Contrary to the isolated clostridial application the combined treatment causes a significant improvement of therapeutic effects (tumour-necrosis and -liquefaction, decreased growth-rate-quotient). The examination of antibody titers against clostridial rods shows in animals with Alloxan-diabetes a more early and more powerful increase in comparison with the isolated clostridial application. The importance of these results for therapy and serological diagnosis of malignant tumours is discussed.
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