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  • Title: Roles of brain prostaglandin E2 and thromboxane A2 in the activation of the central sympatho-adrenomedullary outflow in rats.
    Author: Murakami Y, Okada S, Nishihara M, Yokotani K.
    Journal: Eur J Pharmacol; 2002 Oct 11; 452(3):289-94. PubMed ID: 12359269.
    Abstract:
    We examined the effects of centrally administered active metabolites of the arachidonic acid cascade on activation of the central sympatho-adrenomedullary outflow using urethane-anaesthetized rats. Intracerebroventricularly (i.c.v.) administered prostaglandin E(2) (0.3 nmol/animal) significantly elevated plasma levels of noradrenaline while levels of adrenaline were not affected. Prostaglandin D(2), prostaglandin F(2 alpha) and prostaglandin I(2) at the same dose (0.3 nmol/animal, i.c.v.) had no effect on plasma levels of either catecholamine. Thromboxane A(2) mimetic, 7-[3-[3-hydroxy-4-(4-iodophenoxy)-1-butenyl]-7-oxabicyclo [2.2.1]hept-2-yl], [1S-[1 alpha,2 alpha(Z),3beta(1E,3S),4 alpha]]-5-heptenoic acid (I-BOP) (5 and 10 pmol/animal) microinjected into the paraventricular nucleus of the hypothalamus significantly elevated plasma levels of adrenaline, but had little effect on plasma levels of noradrenaline. The I-BOP-induced (10 pmol/animal) elevation of plasma adrenaline levels was abolished by (+)-(1R,2R,3S,4S)-(5Z)-7-(3-[4-3H]-phenylsulphonyl-aminobicyclo[2.2.1]hept-2-yl)hept-5-enoic acid sodium salt [(+)-S-145] (a blocker of thromboxane A(2) receptors) [625 nmol (250 micro g)/animal, i.c.v.]. These results suggest that brain prostaglandin E(2) and thromboxane A(2) are respectively involved in the activation of the central sympathetic and adrenomedullary outflow in rats.
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