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  • Title: Disparity of mixed lymphocyte reactivity to cultured cells of human T and B lymphoid lines.
    Author: Pauly JL, Minowada J, Han T, Moore GE.
    Journal: J Natl Cancer Inst; 1975 Mar; 54(3):557-62. PubMed ID: 123598.
    Abstract:
    Repeated attempts with difference assays and experimental conditions failed to detect significant peripheral blood lymphocyte reactivity in one-way mixed lymphocyte reactions to irradiated or mitomycin C-treated cells of the "leukemic" T lymphoid line RPMI 8402. In contrast, consistently high levels of peripheral blood lymphocyte reactivity were obtained with cells of six B lymphoid lines established from the same blood sample used to initiate this T lymphoid line. Although attempts to define the reason why these cultured T cells did not initiate a mixed lymphocyte reaction were not successful, evidence indicates that this inability may be an intrinsic characteristic common to three other T lymphoid lines (MOLT-4, CCRF-CEM, and CCRF-HSB-2), also established from patients with relapsed acute lymphoblastic leukemia.
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