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  • Title: [17-ketosteroids in the 24-hour urine of miners with vibration disease from local vibration exposure].
    Author: Kirkov V, Pernov K.
    Journal: Probl Khig; 1975; 1():101-6. PubMed ID: 1235986.
    Abstract:
    The 17-ketosteroid level in the urine secreted in 24 hours s studied in miners with vibration disease. The case material is analyzed according to age, working service, clinical syndromes and stage. It is demonstrated that the continuous effect of local vibrations lead to inhibition of the adrenal function, manifested by a 17-ketosteroids fall. Such a lowering is assumed as one of the adaptational syndrome-manifestations. Regulation of corticosteroid secretion is discussed in the light of complex interrelations--neuroendocrine, biochemical and homeostatic. The role played by oxidation processes is also emphasized. 17-ketosteroids content in the urine has certain diagnostical value, irrespective of the fact that its lowering is by no means a specific manifestation of the vibration disease.
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