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  • Title: Emerging roles of PPARs in inflammation and immunity.
    Author: Daynes RA, Jones DC.
    Journal: Nat Rev Immunol; 2002 Oct; 2(10):748-59. PubMed ID: 12360213.
    Abstract:
    Lipids and lipid metabolism have well-documented regulatory effects on inflammatory processes. Recent work has highlighted the role of the peroxisome proliferator-activated receptors (PPARs)--a subset of the nuclear-hormone-receptor superfamily that are activated by various lipid species--in regulating inflammatory responses. Here, we describe how the PPARs, through their interactions with transcription factors and other cell-signalling systems, have important regulatory roles in innate and adaptive immunity.
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