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  • Title: Unravelling the pathogenesis of myasthenia gravis.
    Author: Vincent A.
    Journal: Nat Rev Immunol; 2002 Oct; 2(10):797-804. PubMed ID: 12360217.
    Abstract:
    Myasthenia gravis is a relatively rare neurological disease that is associated with loss of the acetylcholine receptors that initiate muscle contraction. This results in muscle weakness, which can be life-threatening. The story of how both the physiological basis of the disease and the role of acetylcholine-receptor-specific antibodies were determined is a classic example of the application of basic science to clinical medicine, and it has provided a model for defining other antibody-mediated disorders of the peripheral and central nervous systems.
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