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  • Title: Selective regulation of acid, pepsinogen, and bicarbonate secretion in the stomach by different C-fiber populations of vagus nerve.
    Author: Zolotarev VA, Khropycheva RP, Polenov SA.
    Journal: Bull Exp Biol Med; 2002 Mar; 133(3):210-3. PubMed ID: 12360332.
    Abstract:
    Acute experiments on anesthetized rats showed that group B nerve fibers of the subphrenic portion of the vagus nerve do not participate in the regulation of gastric secretion. Gastric acid production is mainly controlled by fast C-fibers (2.11 0.09 m/sec), while secretion of pepsinogen and bicarbonates depends on activity of both fast and slow (0.95 0.11 m/sec) C-fibers. Some fast conduction C-fibers stimulating the release of bicarbonates in the stomach are capsaicin-sensitive afferents. The local effect of these afferents depends on cholinergic transmission and most probably it is mediated via its modulation.
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