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  • Title: [Effect of atenolol and trimetazidine on dispersion of cardiac rhythm in patients with moderately expressed postinfarction left ventricular dysfunction].
    Author: Kaliuzhin VV, Tepliakov AT, Kamaev DIu, Solovtsov MA.
    Journal: Ter Arkh; 2002; 74(8):42-4. PubMed ID: 12360593.
    Abstract:
    AIM: To study effects of atenolol and trimetazidine on heart rhythm variability in postmyocardial infarction patients with moderate left ventricular dysfunction. MATERIAL AND METHODS: Fifty postmyocardial infarction (PMI) patients participated in a 3-week randomized blind trial. They were divided into two groups given atenolol or trimetazidine. Time and spectral analyses of heart rhythm dispersion on short ECG parts (5 min) were done before and after treatment with atenolol (76.9 +/- 6.6 mg/day) or trimetazidine (60 mg/day). RESULTS: Only course therapy with atenolol raised heart rhythm variability registered both by time and spectral analysis. CONCLUSION: Studying heart rhythm variability enables efficient non-invasive control over effectiveness of neurohumoral heart unloading in the course of pharmacotherapy of ischemic left ventricular dysfunction.
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