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  • Title: Morphologic and functional changes of the microlymphatic network in patients with advancing stages of primary lymphedema.
    Author: Allegra C, Sarcinella R, Bartolo M.
    Journal: Lymphology; 2002 Sep; 35(3):114-20. PubMed ID: 12363221.
    Abstract:
    Using fluorescent microlymphography, we examined the morphology andfunctional characteristics of the microlymph-vascular network in 36 subjects including 9 patients with "compressible" lymphedema (Group I), 14 with minimally compressible lymphedema (Group II), 9 with noncompressible lymphedema (Group III), and 4 healthy individuals. As lymphedema progressedfrom early to advanced stages (Group I-III), an increasingly greater lymphatic capillary density and diameter were depicted and eventually fibrosis/sclerosis with lymphangiectasia, fragmentation and a gradual decrease in the number of microlymphatics. Concomitantly, there was a prolongation in transport and disappearance of fluorescent dye and a progressive increase in endolymphatic and interstitial hydrostatic pressures.
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