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  • Title: Acute ethanol administration produces specific patterns of localization of Fos-immunoreactivity in the cerebellum and inferior olive of two inbred strains of mice.
    Author: Eisenman LM, Tran MH, Scott Donovan H.
    Journal: Brain Res; 2002 Oct 11; 952(1):135-41. PubMed ID: 12363413.
    Abstract:
    Genes play an important role in behavioral responses to ethanol. We examined the response of neurons within the inferior olivary complex (IO) and cerebellum of C57Bl6/J and C3H/HeJ mice to acute ethanol, using immunodetection of Fos (Fos-IR) protein as a marker of neuronal activation. The results demonstrate specific but different patterns of Fos-IR within the IO and cerebellum, especially lobule IX, in each strain. The Fos-IR banding pattern seen in the granule cells of lobule IX is aligned with a previously described banding pattern of Purkinje cells that constitutively expressed heat-shock protein-25 (HSP-25).
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