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  • Title: Characterization of cytokines present in pediatric otitis media with effusion: comparison of allergy positive and negative.
    Author: Jang CH, Kim YH.
    Journal: Int J Pediatr Otorhinolaryngol; 2002 Oct 21; 66(1):37-40. PubMed ID: 12363420.
    Abstract:
    To investigate the possible relationship between allergy and otitis media with effusion (OME), we investigated the cytokine level in the middle ear effusion (MEE)s of children with persistent OME. Interleukin (IL)-2, IL-4, IL-6 and tumor necrosis factor (TNF)-alpha in the MEEs were measured by devised sensitive sandwich enzyme-linked immunosorbent assay (ELISA) and compared allergy positive group with allergy negative group. The mean levels of IL-4, IL-6 and TNF-alpha in MEE were significantly higher in allergy positive group than allergy negative group (P<0.05). Elevation of Th-2-driven cytokines (IL-4, IL-6) and TNF-alpha in MEEs may be a contributing factor in the persistence of OME with allergy.
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