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  • Title: Effect of N-tricyanovinylamines on the level of glutathione in hepatocytes.
    Author: Podhradský D, Paulíková H, Toth G, Miko M.
    Journal: Drug Metabol Drug Interact; 1994; 11(2):111-26. PubMed ID: 12369595.
    Abstract:
    The effects of N-substituted tricyanovinylamines (N-TCVA; RNHC(CN)=C(CN)2) have been studied on rat hepatocytes and liver mitochondria. Derivatives of N-TCVA act on oxidative phosphorylation as uncouplers, and react with thiols within pH 5.0-8.5. N-Isobutyl-, N-benzyl-, and N-cyclohexyl-TCVA influence the level of GSH and GSSG in isolated hepatocytes. They can act as oxidants, but the level of GSSG increases (about 40%) only if the concentration of N-TCVA is higher than 1 micromol/l. If N-TCVA is added to a final concentration higher than 50 micromol/l a decrease of GSH and GSSG level is observed. Derivatives of N-TCVA also influence the level of GSH and GSSG in mitochondria. At 40-400 micromol/l N-TCVA in the incubation medium the level of GSSG increased and the ratio GSH/GSSG was influenced, but the level of total SH groups did not decrease.
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