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  • Title: P1 Phenethyl peptide boronic acid inhibitors of HCV NS3 protease.
    Author: Priestley ES, De Lucca I, Ghavimi B, Erickson-Viitanen S, Decicco CP.
    Journal: Bioorg Med Chem Lett; 2002 Nov 04; 12(21):3199-202. PubMed ID: 12372533.
    Abstract:
    A series of peptide boronic acids containing extended, hydrophobic P1 residues was prepared to probe the shallow, hydrophobic S1 region of HCV NS3 protease. The p-trifluoromethylphenethyl P1 substituent was identified as optimal with respect to inhibitor potency for NS3 and selectivity against elastase and chymotrypsin.
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