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  • Title: Impaired stress-induced pressure natriuresis increases cardiovascularload in African American youths.
    Author: Harshfield GA, Wilson ME, Hanevold C, Kapuku GK, Mackey L, Gillis D, Treiber FA.
    Journal: Am J Hypertens; 2002 Oct; 15(10 Pt 1):903-6. PubMed ID: 12372678.
    Abstract:
    BACKGROUND: We hypothesized that impaired stress-induced pressure natriuresis increases blood pressure (BP) load. METHODS: The 118 African American youths were brought into similar levels of sodium balance. The protocol consisted of a 2-h baseline period, a 1-h stress period (competitive video games), and a 2-h recovery period. RESULTS: Normal pressure natriuresis (n = 80) resulted from a resistance-mediated (r = 0.23; P <.03) increase in BP (P <.001). In contrast, impaired pressure natriuresis (n = 38), leading to an extended period of elevated BP (P <.05), resulted from a volume-mediated (r = 0.55; P <.002) increase in BP (P <.001). CONCLUSIONS: Impaired stress-induced pressure natriuresis may contribute to the development of essential hypertension, particularly in African Americans.
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