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  • Title: Efficacy of inactivated tissue culture rabies vaccine in dogs.
    Author: Strating A, Bunn TO, Goff MT, Phillips CE.
    Journal: J Am Vet Med Assoc; 1975 Nov 01; 167(9):809-12. PubMed ID: 1237485.
    Abstract:
    Inactivated, nonadjuvanted tissue culture-origin rabies vaccine was tested in 168 dogs for its ability to provide protection against challenge of immunity 1 year after vaccination. Several laboratory methods were used concurrently to measure the potency of the vaccine. When used at full strength, the vaccine protected 70% of dogs after either a 1- or 2-dose vaccination schedule. When vaccine was diluted to contain less antigenic mass, the 1-dose schedule was not as effective as 2 doses. High serum-neutralizing antibody titers developed by 7 days after vaccination, but the titers declined rapidly thereafter. The US reference vaccine protected 28 of 30 dogs.
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