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  • Title: Detection of carcinoembryonic antigen in tissue sections by immunoperoxidase.
    Author: Primus FJ, Wang RH, Sharkey RM, Goldenberg DM.
    Journal: J Immunol Methods; 1975 Sep; 8(3):267-75. PubMed ID: 1237519.
    Abstract:
    A triple-bridge, indirect, immunoperoxidase method for detecting and localizing carcinoembryonic antigen (CEA) in tissue sections is described. By this technique, a cell-surface localization of CEA in colonic carcinoma and ovarian mucinous cystadenocarcinoma cells could be visualized. In the case of the colonic cancer, both the tumor from the descending colon and a metastasis to the skin gave positive peroxidase reactions for CEA. This immunocytochemical method for demonstrating the presence of CEA functioned in both frozen, ethanol-fixed and formalin-fixed, paraffin-embedded tissues, thus making it applicable for use with tissue sections conventionally prepared for light microscopy.
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