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  • Title: Increased superoxide radicals generation from alveolar macrophages in immature guinea-pigs.
    Author: Kato M, Tokuyama K, Minakami H, Nagai A, Kozawa K, Goto H, Morikawa A, Kimura H.
    Journal: Cell Biol Int; 2002; 26(9):829-32. PubMed ID: 12377214.
    Abstract:
    To study the effect of maturation on abilities of superoxide radicals (O-2) generation in the airways, we compared stimuli-induced O-2 generation by alveolar macrophages in immature (aged 10+/-2 days) and adult (aged 90+/-2 days) guinea-pigs. The production of O-2 was assayed by chemiluminescence method, using a Cypridina luciferin analog as a highly sensitive and specific probe for O-2. Whereas no significant difference in cell components of bronchoalveolar lavage fluid was observed between immature and adult animals, O-2 generation induced by stimulation of alveolar macrophages was greater in immature than in adult animals, with significant differences observed after platelet-activating factor (100 nM) or phorbol myristate acetate (0.5 micro g/ml). The results suggest that alveolar macrophages from immature animals are far more potent O-2 generators than the same cells of adult animals.
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