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  • Title: Differential effect of cannabinol and cannabidiol on THC-induced responses during abstinence in morphine-dependent rats.
    Author: Hine B, Torrelio M, Gershon S.
    Journal: Res Commun Chem Pathol Pharmacol; 1975 Sep; 12(1):185-8. PubMed ID: 1237925.
    Abstract:
    The same dose of cannabinol (CBN) or cannabidiol (CBD) further increased the attenuation of precipitated abstinence signs observed in morphine-dependent rats that also received an acute dose of delta 9-THC. By contrast, rotational behavior (turning), which is observed concomitantly in THC-treated rats during morphine abstinence, was not increased by CBN, but was potentiated by CBD. These data illustrate differences between psychoinactive cannabinoids in their interaction with delta 9-THC that might be relevant to possible clinical use of Cannabis in narcotic detoxification.
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