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  • Title: Genetic control of phosphate-metabolizing enzymes in Neurospora crassa: relationships among regulatory mutations.
    Author: Littlewood BS, Chia W, Metzenberg RL.
    Journal: Genetics; 1975 Mar; 79(3):419-34. PubMed ID: 123873.
    Abstract:
    In Neurospora crassa, the phosphate-metabolizing enzymes are made during phosphate starvation, but not under phosphate sufficiency. The synthesis of these enzymes is controlled by three regulatory genes: pcon-nuc-2, preg and nuc-1, pcon-nuc-2 and preg are closely linked. A model of the hierarchical relationships among these regulatory genes is presented. Studies of double mutants and revertants confirm several predictions of the model. It has been found that nuc-2 (null) and pcon-c (constitutive) mutations reside in the same cistron. preg-c (constitutive) mutations are epistatic to nuc-2 mutations. nuc-1 (null) mutations are epistatic to all others.
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