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  • Title: Liquorice (Glycyrrhiza glabra) and the adrenal-kidney-pituitary axis in rats.
    Author: Al-Qarawi AA, Abdel-Rahman HA, Ali BH, El Mougy SA.
    Journal: Food Chem Toxicol; 2002 Oct; 40(10):1525-7. PubMed ID: 12387318.
    Abstract:
    The effect of oral administration of a water freeze-dried extract of Glycyrrhiza glabra (liquorice) has been studied at doses of 100, 250 and 500 mg/kg in rats on the plasma concentration of cortisol, adrenocorticotrophic hormone (ACTH), aldosterone, renin, sodium (Na) and potassium (K). The results indicated that treatment induced dose-dependent and mostly significant decreases in the concentration of cortisol, ACTH, aldosterone and K. There were concomitant dose-dependent increases in the concentrations of renin and Na. The results suggest a strong and dose-dependent suppression of the adrenal-pituitary axis, accompanied by stimulation of renin production from the kidney.
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