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  • Title: Variation of proximal tubular reabsorptive capacity by volume expansion and aortic constriction during constancy of peritubular capillary protein concentration in rat kidney.
    Author: Holzgreve H, Schrier RW.
    Journal: Pflugers Arch; 1975 Apr 09; 356(1):73-86. PubMed ID: 1238981.
    Abstract:
    The present study was undertaken in anesthetized rats to examine the effect of aortic constriction and volume expansion on proximal tubular sodium reabsorption during constancy of flow and fluid composition in the peritubular circulation of the kidney. Efferent arterioles and branch capillaries were perfused at 625 nl/min with an artificial perfusate containing 9 g per oiter of albumin both before and during either aortic constriction or saline infusion. Results of recollection micropuncture studies in those tubules surrounded by artificially perfused capillaries were compared with results in control tubules in which the peritubular capillary flow and fluid composition were allowed to change during aortic constriction or volume expansion following saline infusion. Changes in single nephron filtration rate, fractional and absolute reabsorption induced by both aortic constriction and saline infusion were found to be qualitatively and quantitatively comparable in tubules with constant peritubular capillary microperfusion and in the control tubules with changing peritubular capillary environment due to the experimental maneuvers. Taken together, therefore, the present results indicate that with the use of the peritubular microperfusion technique no evidence is found to support a role of alteration in the peritubular environment in modulating the effect of aortic constriction or saline infusion on tubular sodium reabsorption in the rat nephron. Rather, these results provide indirect evidence in support of intraluminal factors as mediating these responses in tubular reabsorption to volume expansion and aortic constriction.
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