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  • Title: [Enhanced sensitivity of ovarian cell line to cisplatin induced by mifepristone and its mechanism].
    Author: Qin TN, Wang LL.
    Journal: Di Yi Jun Yi Da Xue Xue Bao; 2002 Apr; 22(4):344-6. PubMed ID: 12390742.
    Abstract:
    OBJECTIVE: To observe the effect of mifepristone in enhancing chemosensitivity of drug-resistant ovarian cancer cell line to cisplatin and investigate its mechanism. METHODS: Human ovarian cancer cell lines COC1 (DDP-sensitive) and COC1/DDP (DDP-resistant) were incubated with or without mifepristone. The proliferation rate of the cells was determined by methyl thiazolyl tetrazolium (MTT) assay and positive expression of apoptosis-associated proteins Bcl-2 and Bax were observed by means of flow cytometry. RESULTS: It was observed that mifepristone at the dose of 1.25 micromol/L reversed the resistance of COC1/DDP cells to cisplatin, and Bcl-2 protein expression was deceased from (23.8067+/-0.4382)% to (19.3967+/-0.6866)% (P=0.000) while Bax protein expression increased from (12.75+/-0.2524)% to (25.5967+/-0.8834)% (P=0.000). CONCLUSION: Mifepristone may act to enhance the sensitivity of COC1/DDP cells to cisplatin, possibly through regulating Bcl-2 and Bax protein expressions.
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