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  • Title: Antiproliferative sesquiterpene lactones from the roots of Inula helenium.
    Author: Konishi T, Shimada Y, Nagao T, Okabe H, Konoshima T.
    Journal: Biol Pharm Bull; 2002 Oct; 25(10):1370-2. PubMed ID: 12392098.
    Abstract:
    The MeOH extract of the roots of Inula helenium showed a high inhibitory activity for cell growth against MK-1, HeLa and B16F10 cell lines. Significant activity was found in the hexane-soluble fraction. From the hexane-soluble fraction, seven sesquiterpenes, namely, one germacrane (4beta,5alpha-epoxy-1(10),11(13)-germacradiene-8,12-olide), one elemane (igalane), and five eudesmanes (alantolactone, isoalantolactone, 11alpha,13-dihydroalantolactone, 11alpha,13-dihydro-isoalantolactone, 5-epoxyalantolactone) were isolated. In vitro antiproliferative activities of the isolates against MK-1, HeLa and B16F10 cells are reported.
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