These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
    Author: Perron-Sierra F, Saint Dizier D, Bertrand M, Genton A, Tucker GC, Casara P.
    Journal: Bioorg Med Chem Lett; 2002 Nov 18; 12(22):3291-6. PubMed ID: 12392735.
    Abstract:
    A novel series of potent and specific alpha(v) integrin antagonists has been obtained by aminoalkyl substitutions on benzocyloheptene acetic acids as a rigid GD bioisostere. The preferred compounds 1-2, 1-3 and 1-8, showed nano- to subnanomolar IC(50) values on alpha(v)beta(3) and alpha(v)beta(5) integrins, with favorable pharmacokinetics.
    [Abstract] [Full Text] [Related] [New Search]