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  • Title: Effect of cycloheximide on viral precursor protein B in Sindbis virus-infected BHK cells.
    Author: Duda E.
    Journal: Med Biol; 1975 Oct; 53(5):368-71. PubMed ID: 1239649.
    Abstract:
    The possible role of B protein, a postulated precursor of viral envelope proteins was studied in Sindbis virus-infected BHK cells. Although tryptic digestion of the B protein produces tryptic peptides of the viral envelope proteins it seems unlikely that B molecules accumulated in the cytoplasm of infected cells are subsequently cleaved into structural proteins. We suggest that if B is really the precursor of E1 and PE2 viral envelope proteins, the cleavage takes place on the ribosomes during the synthesis of the second part of the B protein. Low concentrations of cycloheximide completely blocked the synthesis of B protein but did not inhibit the synthesis of viral structural proteins.
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