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  • Title: Distribution of thymidine phosphorylase activity in gastric carcinoma and adjacent normal gastric tissue.
    Author: Sugiyama A, Maruta F, Tsuzuki S, Murakami M, Kawasaki S.
    Journal: Hepatogastroenterology; 2002; 49(48):1734-6. PubMed ID: 12397781.
    Abstract:
    BACKGROUND/AIMS: Thymidine phosphorylase was reported to be identical to the angiogenic factor, platelet-derived endothelial cell growth factor. In this study we investigated the distribution of thymidine phosphorylase activity in human gastric carcinoma or normal gastric tissue using the ELISA system. METHODOLOGY: A longitudinal slice in the center of the gastric carcinoma of resected specimens from 6 patients with gastric carcinoma was used, and thymidine phosphorylase activity was mapped in each case. RESULTS: In all cases, the thymidine phosphorylase activities were significantly higher in tumors than adjacent normal gastric tissues. The amount and distribution of thymidine phosphorylase activity were different between intestinal-type and diffuse-type carcinoma. The thymidine phosphorylase activities in the invasive front of tumor were significantly lower than those in the other part in intestinal-type carcinoma. CONCLUSIONS: The ELISA system used in this study proved useful for the determination of thymidine phosphorylase activities in tissue sections.
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