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Title: The Arabidopsis RRS1-R disease resistance gene--uncovering the plant's nucleus as the new battlefield of plant defense? Author: Lahaye T. Journal: Trends Plant Sci; 2002 Oct; 7(10):425-7. PubMed ID: 12399170. Abstract: The isolation of over 30 plant disease-resistance genes revealed that most genes encode putatively cytoplasmic proteins with a nucleotide-binding site (NBS) and a leucine-rich repeat (LRR). However, the recent isolation of the Arabidopsis RRS1-R gene has uncovered a novel NBS-LRR subtype that harbors a C-terminal extension with a putative nuclear localization signal and a DNA-binding domain that is characteristic of the WRKY transcription factor family. This suggests that RRS1-R, unlike any other known R protein, is targeted to the nucleus to fulfill its function.[Abstract] [Full Text] [Related] [New Search]