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  • Title: Carotid ultrasound backscatter analysis in hypertensive and in healthy subjects.
    Author: Rossi M, Cupisti A, Perrone L, Santoro G.
    Journal: Ultrasound Med Biol; 2002 Sep; 28(9):1123-8. PubMed ID: 12401381.
    Abstract:
    The purpose of this study was to evaluate, by integrated backscatter (IBS) analysis, the influence of arterial hypertension on the carotid ultrasound (US) reflectivity and the age-related changes of this parameter. We recruited 20 middle-aged hypertensive patients free from other major cardiovascular risk factors and 20 gender- and age-matched healthy control subjects. An additional 30 healthy subjects, 15 younger than 30 years old and 15 older than 65 years old were also recruited. The "calibrated" IBS (C-IBS) of the left carotid "distant" wall, calculated as the difference between the IBS mean value (62 measurements) of intima-media (IM) complex and the IBS mean value of adventitia (62 measurements), was significantly higher in those with hypertension than in the age-matched controls, but similar between those with hypertension and the elderly subjects. In the 50 healthy subjects, the C-IBS was positively related to age (r = 0.40; p < 0.01) and to carotid IM thickness (r = 0.33; p < 0.05). Our study shows an increased US reflectivity of carotid wall in hypertensive patients and a positive relation of this parameter to age in the healthy population, suggesting that IBS analysis can be an useful tool to detect a vascular change related to hypertension and to aging.
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