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  • Title: Drugs targeting the renin-angiotensin-aldosterone system.
    Author: Zaman MA, Oparil S, Calhoun DA.
    Journal: Nat Rev Drug Discov; 2002 Aug; 1(8):621-36. PubMed ID: 12402502.
    Abstract:
    Effective antihypertensive therapy has made a major contribution to the reductions in the morbidity and mortality of cardiovascular disease that have been achieved since the 1960s. However, blood-pressure control with conventional drugs has not succeeded in reducing cardiovascular disease risks to levels seen in normotensive persons. Drugs that inhibit or antagonize components of the renin-angiotensin-aldosterone system are addressing this deficiency by targeting both blood pressure and related structural and functional abnormalities of the heart and blood vessels, thus preventing target-organ damage and related cardiovascular events.
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