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  • Title: [Changes in systemic hemodynamics following administration of synthetic angiotensin II to dogs of different ages].
    Author: Brin VB.
    Journal: Biull Eksp Biol Med; 1975 Nov; 80(11):14-7. PubMed ID: 1240780.
    Abstract:
    Experiments were conducted on dogs aged 18-22 days, 2-3 month-old and adult dogs. Arterial blood pressure, cardiac output, heart rate and total peripheral resistance during the infusion of synthetic angiotensin-II-amide in a dose of 2 mug/kg per minute were studied. An increase of arterial pressure in adult dogs during the action of angiotensin-II was connected with the elevation of the total peripheral resistance. An increase of the total peripheral resistance and also of the cardiac output was seen in the puppies. The differences in the degree of increase of the arterial blood pressure in adult dogs and puppies were not marked.
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