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  • Title: mRNA at synapses, synaptic plasticity, and memory consolidation.
    Author: Steward O.
    Journal: Neuron; 2002 Oct 24; 36(3):338-40. PubMed ID: 12408837.
    Abstract:
    Miller et al. (this issue of Neuron) report that deletion of the 3'UTR of alpha-CaMKII mRNA prevents dendritic delivery of the mRNA in transgenic mice and thus local synthesis of alpha-CaMKII protein in dendrites. 3'UTR mutant mice exhibit decreases in alpha-CaMKII protein in postsynaptic densities, and deficits in late phase LTP and in memory consolidation.
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