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  • Title: Dueling activities of AIF in cell death versus survival: DNA binding and redox activity.
    Author: Lipton SA, Bossy-Wetzel E.
    Journal: Cell; 2002 Oct 18; 111(2):147-50. PubMed ID: 12408857.
    Abstract:
    Apoptosis-inducing factor (AIF) was originally discovered as a mitochondrial protein that, like cytochrome c, is released into the cytoplasm during cell death. New evidence suggests, however, that a redox-active enzymatic region of AIF may be antiapoptotic while a DNA binding region is proapoptotic.
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