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  • Title: Isolation and structural studies of coprine, the disulfiram-like constituent of Coprinus atramentarius.
    Author: Hatfield GM, Schaumberg JP.
    Journal: Lloydia; 1975; 38(6):489-96. PubMed ID: 1241098.
    Abstract:
    Coprine, the constituent of the mushroom Coprinus atramentarius Fr. responsible for its disulfiram-like activity, was isolated. Chemical and spectral data indicate that the compound is N5-(1-hydroxycyclopropyl)glutamine. Although coprine was shown to produce hyperaldehydemia in mice following ethanol ingestion, the compound was not found to be an inhibitor of mouse liver aldehyde dehydrogenase in vitro.
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