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  • Title: Experimental study on effects of vitamin B(6) on dexamethason-induced palatal cleft formation in the rat.
    Author: Zhang S, Yuan W.
    Journal: Zhonghua Kou Qiang Yi Xue Za Zhi; 2002 Jul; 37(4):272-4. PubMed ID: 12411174.
    Abstract:
    OBJECTIVE: To evaluate whether or not administration of vitamin B(6) (vitB(6)) has preventive effects on cleft palate formation. METHODS: On the 14, 15 day of gestation, the pregnant rats were treated with administration of vitB(6) (10 mg/kg weight im) before and simultaneously with dexamethason (DEX). Compared the palatal cleft incidence of their fetuses with those whose mother were given DEX only. RESULTS: Treatment with administration of vitB(6) before and simultaneously with DEX, the palatal cleft incidence of subject group fetuses (32.35%) was significantly less than that given DEX only (64.52%). The proportion of the palatal cleft type was also changed significantly. CONCLUSIONS: VitB(6) decrease both the incidence and the severity of cleft palate induced by DEX in rats, which indicates VitB(6) may have preventive effects on cleft palate formation.
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