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  • Title: [Estrogenic action of cardiac glycosides. Clinical and animal experiment studies].
    Author: Hofmann P, Häffele R, Buchholz C.
    Journal: Fortschr Med; 1975 Sep 25; 93(27):1274-6. PubMed ID: 1241381.
    Abstract:
    Vaginal smears of young girls before puberty and of postmenopausal women who were treated with digoxine, were examined on their degree of proliferation. There was no sign of any estrogenic stimulation. In female juvenile and ovarectomized fertile rats digitoxin caused no ripening of the vaginal epithelium neither in low nor in high doses. It is supposed that some steroid-hormone-like effects which are seen by glycoside-therapy, are related to stimulation of the suprarenal gland.
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