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  • Title: Behavioral supersensitivity to apomorphine and amphetamine after chronic high dose haloperidol treatment.
    Author: Smith RC, Davis JM.
    Journal: Psychopharmacol Commun; 1975; 1(3):285-93. PubMed ID: 1241453.
    Abstract:
    Rats administered chronic haloperidol (5 mg/cc) for 2 months exhibited stereotyped gnawing during chronic haloperidol treatment, and after withdrawal from haloperidol, showed significantly greater stereotyped behavior induced by apomorphine or L-amphetamine compared to saline controls. Chronic administration of benztropine mesylate concomitantly with haloperidol reduced the effects of chronic haloperidol on drug induced stereotyped behavior during the withdrawal period.
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