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  • Title: Z-ajoene induces apoptosis of HL-60 cells: involvement of Bcl-2 cleavage.
    Author: Li M, Min JM, Cui JR, Zhang LH, Wang K, Valette A, Davrinche C, Wright M, Leung-Tack J.
    Journal: Nutr Cancer; 2002; 42(2):241-7. PubMed ID: 12416266.
    Abstract:
    Garlic organosulfur components exhibit antitumor activity, but the molecular mechanisms underlying these effects have not been well characterized. We showed that Z-ajoene, a sulfur-rich compound purified from garlic, induced time- and dose-dependent apoptosis in HL-60 cells. This process implied the activation of caspase-3 and the cleavage of the antiapoptotic protein Bcl-2. The caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-[OMe]-fluoromethylketone inhibited Bcl-2 cleavage and apoptosis induced by Z-ajoene. This effect was partially prevented by treatment of HL-60 cells with the antioxidant N-acetylcysteine. Hence, the transmission of apoptotic signal induced by Z-ajoene involved a reactive oxygen species-dependent pathway leading to caspase-dependent Bcl-2 cleavage.
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