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  • Title: Understanding the unique mechanism of L-FMAU (clevudine) against hepatitis B virus: molecular dynamics studies.
    Author: Chong Y, Chu CK.
    Journal: Bioorg Med Chem Lett; 2002 Dec 02; 12(23):3459-62. PubMed ID: 12419383.
    Abstract:
    The molecular dynamics simulation of HBV-polymerase.DNA.L-FMAU-TP complex demonstrated that L-FMAU-TP may not serve as a substrate for HBV polymerase because the appropriate binding of L-FMAU-TP to the active site of HBV polymerase may not take place without the unfavorable conformational adjustment, which prevents L-FMAU-TP from being incorporated into the growing viral DNA chain.
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