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  • Title: Synthesis and in vitro antiprotozoal activity of 5-nitrothiophene-2-carboxaldehyde thiosemicarbazone derivatives.
    Author: Bharti N, Husain K, Gonzalez Garza MT, Cruz-Vega DE, Castro-Garza J, Mata-Cardenas BD, Naqvi F, Azam A.
    Journal: Bioorg Med Chem Lett; 2002 Dec 02; 12(23):3475-8. PubMed ID: 12419387.
    Abstract:
    Several thiosemicarbazone derivatives of 5-nitrothiophene-2-carboxaldehyde were prepared by the simple process in which N(4)-thiosemicarbazone moiety was replaced by aliphatic, arylic and cyclic amine. Among these thiosemicarbazones compound 11 showed significant antiamoebic activity whereas compound 3 was more active antitrichomonal than the reference drug.
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