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  • Title: Effects of ergothioneine on diabetic embryopathy in pregnant rats.
    Author: Guijarro MV, Indart A, Aruoma OI, Viana M, Bonet B.
    Journal: Food Chem Toxicol; 2002 Dec; 40(12):1751-5. PubMed ID: 12419688.
    Abstract:
    The natural antioxidant ergothioneine (2-mercaptohistidine trimethylbetaine) is a fungal metabolite and found in most plant and animal tissues. The effect of ergothioneine on diabetic embryopathy in rats was assessed. Supplementation of diabetic pregnant rats with L-ergothioneine (1.147 mg/kg body weight) daily for the first 11.5 days of pregnancy reduced the rate of embryo malformations, to values similar to the non-diabetic animals. The ergothioneine had no effect on the plasma glucose levels, both in diabetic and control animals. We conclude that the inhibition of the glucose-mediated free radical dependent embryo malformation by ergothioneine is an important antioxidant prophylactic mechanism, which when combined with vitamin E could benefit the management of diabetic embryopathy.
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