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  • Title: [Serum neopterin and beta2-microglobulin concentration as "prognostic markers" of AIDS].
    Author: Halota W, Jaruga B, Pawłowska M.
    Journal: Pol Merkur Lekarski; 2002 Aug; 13(74):126-8. PubMed ID: 12420343.
    Abstract:
    UNLABELLED: The aim of the study was evaluation of serum neopterin and beta 2-microglobulin concentrations as "prognostic markers" of AIDS natural history. MATERIAL AND METHODS: Investigations was performed in 68 patients (48 hiv-infected and 20 without hiv-infection), who were divided into 3 groups according to HIV CDC classification. RESULTS: The highest serum concentrations of neopterin and beta 2-microglobulin were detected in patients with AIDS. In a non-symptomatic HIV-infected patients p24 Ag was absent. It was detected in patients with AIDS. Negative correlation between neopterin and beta 2-microglobulin serum concentration and CD4 count was detected in sera from all patients. Positive correlation was observed between p24 Ag, serum neopterin and beta 2-microglobulin concentration in patients with AIDS. CONCLUSIONS: Progression of HIV infection was connected with an increase of serum neopterin and beta 2-microglobulin serum concentrations. Neopterin serum concentration seems to be a more sensitive marker of HIV infection than beta 2-microglobulin.
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