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  • Title: Studies on the intrathecal pharmacotherapy. Part I: CDP-choline.
    Author: Ogashiwa M, Takeuchi K, Hara M, Tanaka Y, Okada J.
    Journal: Int J Clin Pharmacol Biopharm; 1975 Oct; 12(3):327-35. PubMed ID: 1242132.
    Abstract:
    A study was made of the intrathecal infusion as a route of administration of drugs for the CNS, by giving due consideration to the presence of blood-brain and CSF-brain barriers. CDP-choline was used as the brain activator, and the effect of the drug intrathecally infused was investigated both clinically and by experiments on animals. Seven patients with a disturbance of consciousness due to primary brain lesion received a total of 19 intrathecal infusions of CDP-choline, and were examined for the effect of the treatment neurologically and electroencephalographically. Wistar rats were infused either intravascularly or intracisternally with 14C-CDP-choline, and the distribution in the body was investigated by whole body autoradiography.
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